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KMID : 0356019920070020105
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Koean Jounral of Critical Care Medicine
1992 Volume.7 No. 2 p.105 ~ p.112
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The Experimental Study on the Effects of Ringer's Lactate and Pentastarch Infusion in Hemorrhagic Dogs
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김욱성
권재영/김해규/김인세/정규섭
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Abstract
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Volume expansion is frequently required in critically ill patients exhibiting hypovolemia often related to trauma and operation. Fluid infusion is very important for the resuscitation of hypovolemia. But, the type of fluid infused is remained
controversial. Twelve anesthetized dogs were bled(35 ml/kg) and resuscitated with Ringer's lactate infusion (100 ml/kg) or pentastarch infusion (35 ml/kg). Physiologic variables were measured initialy, post-hemorrhagic period, post-infusin
period.
@ES The results are as follows
@EN 1) Hemoglobin and hematocrit were marked decreased via hemodilution at each group, so oxygen carring capacty was also decreased.
2) Prothrombin time and partial thromboplastin time were prolonged on both group, but pentastarch group were more prolonged than Ringer's lactate group.
3) In blood gas analysis, metabolic acidosis was appeared after hemorrhage, but recovered after fluid infusion in both group.
4) In hemodynamic study, pentastarch group was better maintained cardiac output, blood pressure and central venous pressure than Ringer's lactate group.
From this study, Ringer's lactate and pentastarch infusion is effective for the treatment of bemorrhagic shock. But pentastarch infusion is more effective in maintaining circulating blood volume than Ringer's lactate infusion.
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